Malariotherapy was first documented as an experimental clinical trial in the treatment of neurosyphilis during the early 1940s by Julius Wagner-Jauregg, one of three known psychiatrists to have won the Nobel Prize. Due to the emergence of bioethics, discovery of penicillin as an antibiotic alternative for the curation of syphilis and the fall from grace of Wagner-Jauregg, malarial therapy was side-lined and phased out. However as a result of the emergence of antibiotic resistance in syphilis patients to their drugs, we decided to undertake this study to determine the success margins that malarial therapy would have over penicillin use for curation of syphilis. A random sampling of 120 subjects from 5 different areas in Kenya, of both male and female genders and indiscriminately of ethnicity, was conducted in psychiatric institutions. The study looked to observe the cerebrospinal fluid(CSF) values and serum rapid plasma reagin titers of the selected participants, monitoring their baseline abnormalities over a 6 weeks’ period of grouped treatment. The results yielded provided for analytical assessment which showed no statistically significant differences in the medians of the successes for both malariotherapy and penicillin g treatment. We concluded that despite the insignificance in median differences for the success rates, malariotherapy had more successes and would provide a cheaper option for syphilis treatment. We recommended further research into this area, with heavy emphasis on a larger sample size and prolonged research period.